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一种雄性类固醇控制着疟疾蚊子的雌性性行为

Duo Peng¹, Evdoxia G Kakani^1,2, Enzo Mameli^1,3

¹Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

|July 6, 2022

概括

疟疾蚊子使用不同的类固醇激素进行繁殖. 雄性转移激素降低了雌性受体,并有助于卵子发育,可能有助于控制疟疾.

科学领域:

昆虫学
生殖生物学
内分泌学

背景情况:

脊椎动物具有偏向男性的性类固醇激素,与以前认为缺乏这些激素的昆虫不同.
在Anopheles gambiae中,20-hydroxyecdysone (20E) 控制了雌性卵子的发育和雄性诱导的交配阻断性.
了解Anopheles gambiae的生殖激素调节对于开发新的疟疾控制策略至关重要.

研究的目的:

为了研究不同的性别类固醇调节生殖功能在Anopheles gambiae.
为了确定雌性将卵子发育和交配行为的荷尔蒙信号集成的机制.
探索向这些荷尔蒙途径以控制疟疾载体的潜力.

主要方法:

鉴定和描述男性特异性的氧化体.
对生态类固醇激活/非激活酶网络的分析
对类固醇激素转移和Plasmodium感染的基因表达分析.

主要成果:

鉴定出一种男性特异性的3-dehydro-20E (3D20E),可降低女性移植后的性接受力.
3D20E转移还可以提高一个促进卵子发育的基因.
女性衍生的20E通过抑制抑制性激酶来促进交配后的卵置,这与男性诱导的折射性不同.

结论:

在Anopheles gambiae中,繁殖功能由不同的性别类固醇和酶途径控制.
男性特异性激素3D20E在保证父亲身份和在感染期间增强女性健康方面发挥着双重作用.
针对这些昆虫特有的类固醇激素机制,

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