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在B细胞淋巴瘤中,超增强剂高突变改变了瘤基因表达

Elodie Bal1, Rahul Kumar1,2, Mohammad Hadigol3

  • 1Institute for Cancer Genetics, Columbia University, New York, NY, USA.

Nature
|July 6, 2022
PubMed
概括

扩散性大B细胞淋巴瘤 (DLBCL) 涉及超级增强剂的突变,对基因调节至关重要. 这些突变会影响BCL6,BCL2和CXCR4等基因,为这种常见的非霍奇金淋巴瘤提供新的治疗点.

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