通过条形电路显示对手的并行控制
Bruno F Cruz1, Gonçalo Guiomar1, Sofia Soares1,2
1Champalimaud Neuroscience Programme, Champalimaud Research, Champalimaud Foundation, Lisbon, PT, Portugal.
Nature
|July 6, 2022
概括
基底腺
科学领域:
- 神经科学
- 计算神经科学
- 发动机控制
背景情况:
- 基底的直接和间接途径传统上被视为分别促进和抑制行为.
- 带状直接和间接中等脊髓神经元 (dMSN和iMSN) 的协同激活挑战了这一经典模型.
- 了解基底腺功能对于解释动作启动和抑制至关重要.
研究的目的:
- 调查直接和间接途径在行动促进和抑制中的不同作用.
- 在行动抑制过程中探索dMSN和iMSN之间的功能对立性.
- 阐明特定区域的基底腺回路如何对行为控制作出贡献.
主要方法:
- 在执行间隔分类任务的小鼠中研究基底腺回路.
- 使用光纤测量和照片识别的电生理记录.
- 使用光遗传抑制和计算强化学习模型.
主要成果:
- 在背侧条纹体 (DLS) 中抑制作用时观察到dMSN和iMSN之间的功能对立性.
- 发现DLS电路主要抑制,而不是促进,行动.
- 证明iMSN抑制反侧作用,而dMSN在脊髓中条状体促进它.
结论:
- 基底回路和区域之间的对立相互作用使行为控制成为可能.
- 感官运动间接途径在主动抑制诱惑行为中起着关键作用.
- 状回路在运动控制中表现出特定区域的功能.
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