相关实验视频

Updated: Apr 13, 2026

Chromatin Interaction Analysis with Paired-End Tag Sequencing ChIA-PET for Mapping Chromatin Interactions and Understanding Transcription Regulation
21:55

Chromatin Interaction Analysis with Paired-End Tag Sequencing ChIA-PET for Mapping Chromatin Interactions and Understanding Transcription Regulation

Published on: April 30, 2012

31.3K

主要结构和转录调节GAP-43,与神经生长相关的蛋白质

G S Basi, R D Jacobson, I Virág

    Cell
    |June 19, 1987
    PubMed
    概括

    增长相关蛋白43 (GAP-43) 对于神经再生和轴突发育至关重要. 它的基因表达,主要在神经元中,在转录水平上受到调节,影响神经可塑性.

    更多相关视频

    A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide11:02

    A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide

    Published on: October 18, 2014

    10.4K
    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein05:48

    Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

    Published on: March 16, 2022

    3.1K

    相关概念视频

    Transcription01:10

    Transcription

    Overview
    Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
    Transcription Can Produce Different Kinds...
    160.5K
    RNA Polymerase II Accessory Proteins02:36

    RNA Polymerase II Accessory Proteins

    Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
    11.5K
    Cis-regulatory Sequences02:02

    Cis-regulatory Sequences

    Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
    12.3K
    Transcription01:17

    Transcription

    Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
    Transcription Can Produce Different Kinds of RNA Molecules
    In eukaryotes,...
    36.6K
    General Transcription Factors01:30

    General Transcription Factors

    Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
    7.8K
    Regulation of Expression at Multiple Steps01:23

    Regulation of Expression at Multiple Steps

    The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
    1.6K