HGT 在昆虫中广泛存在,并在类中促进雄性求爱
Yang Li1, Zhiguo Liu1, Chao Liu2
1Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China.
Cell
|July 19, 2022
概括
水平基因转移 (HGT) 显著影响了昆虫的进化,昆虫从不同的捐赠者获得了1400多个新基因. 这些基因,特别是那些有内核的基因, 增强了适应能力,
科学领域:
- 进化生物学
- 基因组学
- 分子生物学
背景情况:
- 水平基因转移 (HGT) 是一个关键的进化机制.
- 在各种生物体中观察到HGT,但对昆虫的研究较少.
- 昆虫代表了绝大多数动物物种.
研究的目的:
- 系统地研究HGT在昆虫中的程度和影响.
- 在昆虫基因组中识别新的HGT获取基因及其功能.
- 了解HGT在昆虫适应和进化的作用.
主要方法:
- 分析了218个高质量的昆虫基因组.
- 通过HGT获得的基因的识别和表征.
- 进行比较基因组分析以追踪基因起源.
- 基因表达分析比较含内基因和缺乏内基因的HGT基因.
- 在钻石背中进行CRISPR-Cas9基因编辑以研究基因功能.
主要成果:
- 从741个不同的转移中发现了1410个HGT获得的基因,其中许多以前没有报告过.
- 类动物的HGT基因平均数量最高.
- 含有Intron的HGT基因表达水平显著更高.
- 由和蝶的祖先获得的LOC105383139基因得到了功能验证.
- 在钻石背中失去LOC105383139减少了雄性求爱行为.
结论:
- HGT是主要的进化力量,对昆虫的适应有显著的贡献.
- 通过HGT获得的基因的适应可能会得到促进.
- 它引入了功能性新基因, 影响昆虫的复杂行为.
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