综合疫苗组引起的欧米克朗尖峰功能和中和活性
John E Bowen1, Amin Addetia1, Ha V Dang2
1Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Science (New York, N.Y.)
|July 20, 2022
概括
像BA.2和BA.5这样的Omicron亚系显示严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 疫苗的免疫逃避. 然而,增强剂显著增强中和抗体,提供对严重的Omicron疾病的保护.
科学领域:
- 病毒学
- 免疫学
- 疫苗学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) Omicron变种具有多个亚系 (例如,BA.2,BA.4,BA.5).
- 这些亚系表现出尖端蛋白的突变,影响病毒性质和免疫反应.
研究的目的:
- 调查Omicron亚系突变对ACE2结合,融合性和疫苗引起的抗体的中和的影响.
- 评估增剂在恢复对Omicron亚系的中和活性方面的有效性.
主要方法:
- 评估了对Omicron亚系的血管酶转化酶2 (ACE2) 结合和细胞融合.
- 测量感染或接种祖先SARS-CoV-2疫苗的个体的血中和活性.
- 评估同源和异源增剂对中和抗体标位和宽度的影响.
主要成果:
- 与原始病毒相比,Omicron亚系表现出增强的ACE2结合性和降低的融合性.
- 在初级疫苗接种或感染后,对Omicron亚系的中和活性有显著的减弱.
- 增强剂量,特别是基于武汉-胡-1突发序列的剂量,显著增加了对所有测试的Omicron亚系的中和抗体标位和范围.
结论:
- 奥米克朗亚系可以逃避初级疫苗系列产生的中和抗体反应.
- 疫苗增强剂对于增强保护至关重要,并可能提供足够的免疫力来对抗由Omicron亚系引起的严重疾病.
更多相关视频
06:08Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
Published on: September 8, 2023
1.3K
10:25Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
4.8K
相关概念视频
01:29Immune Response Against Viral Pathogens
909
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
909
00:42Cross-reactivity
31.5K
Overview
31.5K
01:51Vaccinations
45.3K
Overview
45.3K
00:56Viral Structure
63.4K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
63.4K
02:50Conjugated Proteins
18.5K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.5K