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通过抑制自发ZBP1激活,ADAR1可以预防自身炎症

Richard de Reuver1,2, Simon Verdonck1,2, Evelien Dierick1,2

  • 1VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Nature
|July 21, 2022
PubMed
概括

编辑RNA的酶ADAR1通常会阻止自身RNA引发免疫反应. 失去ADAR1会激活ZBP1,导致细胞死亡和炎症,导致艾卡迪-古蒂耶综合征.

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