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通过ADAR1阻止ZBP1引发致命的I型干扰素

Huipeng Jiao1,2, Laurens Wachsmuth1,2, Simone Wolf1,2

  • 1Institute for Genetics, University of Cologne, Cologne, Germany.

Nature
|July 21, 2022
PubMed
概括

通过结合Z-RNA,ADAR1通常可以防止有害的I型干扰素反应. 它的缺失使ZBP1能够激活这些反应,导致疾病. 缺少ZBP1可以保护缺乏功能ADAR1的小鼠.

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