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ADAR1突变导致ZBP1依赖的免疫病理

Nicholas W Hubbard1, Joshua M Ames1, Megan Maurano1

  • 1Department of Immunology, University of Washington, Seattle, WA, USA.

Nature
|July 21, 2022
PubMed
概括

编辑RNA的酶ADAR1通常会抑制天生的免疫力. 它的Z-DNA结合域 (ZBD) 改变会通过激活ZBP1导致自身炎症,ADAR1通常会抑制这种途径.

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