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限制运动:细胞大小的脂质囊中的活性微粒的运动性

Shidong Song1, Antoni Llopis-Lorente1,2, Alexander F Mason1

  • 1Department of Chemical Engineering and Chemistry, Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Het Kranenveld 14, 5600 MB Eindhoven, The Netherland.

Journal of the American Chemical Society
|July 22, 2022
PubMed
概括

将活性颗粒限制在像巨型单囊 (GUV) 这样的小区中,会降低它们的运动性. 这项研究揭示了水力动力学效应在这些受限制的3D环境中主导了粒子运动.

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In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
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