用于生物学和医学的组织生物打印
Mohsen Akbari1, Ali Khademhosseini2
1Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada; Biotechnology Center, Silesian University of Technology, Akademicka 2A, Gliwice, 44-100 Poland; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, USA.
Cell
|July 22, 2022
概括
生物打印结合了增材制造和组织工程来创造功能性组织和器官. 这篇综述涵盖了最近生物打印技术的进步和广泛医疗应用的挑战.
科学领域:
- 生物技术
- 复原医学
- 添加剂制造
背景情况:
- 生物打印将增材制造与组织工程原理相结合.
- 这一领域最近取得了显著的进步和快速增长.
- 功能性组织和器官的产生是主要目标.
研究的目的:
- 审查最近生物打印技术的突破.
- 确定和讨论目前阻碍临床翻译的挑战.
- 提供医学生物打印的前景.
主要方法:
- 对最近的科学文献和生物打印技术的发展进行了回顾.
- 分析生物墨水,印刷技术和细胞采购方面的关键创新.
- 讨论与血管化,可扩展性和监管批准有关的挑战.
主要成果:
- 突出了复杂组织结构的重大进展.
- 确定包括长期生存和免疫排斥在内的关键挑战.
- 展示生物油墨配方和打印分辨率的进展.
结论:
- 生物打印正在迅速向临床应用发展.
- 克服血管化和整合方面的挑战对于成功至关重要.
- 需要持续创新才能在再生医学中得到广泛应用.
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