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Updated: Sep 3, 2025

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在胃化过程中TET蛋白的内在和外在作用

Saifeng Cheng1, Markus Mittnenzweig2, Yoav Mayshar1

  • 1Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001 Rehovot, Israel.

Cell
|July 31, 2022
PubMed
概括

十一转位 (TET) 基因损失导致胚胎死亡. 缺乏TET的细胞可以在野生类型胚胎中分化,但只有突变胚胎不能在早期发育,从而显示出细胞自主性的TET功能.

关键词:
DNA 脱甲基化细胞命运决定发育生物学表观遗传学基因组编辑小鼠的胃化单细胞基因组学干细胞

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