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Updated: Sep 2, 2025

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
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Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy

Published on: September 12, 2019

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[7]uril 光学指纹宏循环传感器:预测蛋白质结构变化以识别疾病特异性粉样组合

Nilanjana Das Saha1,2, Soumen Pradhan2, Ranjan Sasmal1

  • 1New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India.

Journal of the American Chemical Society
|August 1, 2022
PubMed
概括

一个新型的光传感器使用库库比特[7]uril (CB[7]) 创建独特的生物分子指纹. 这种方法可以识别蛋白质,检测错误折叠,甚至在临床血清样本中区分粉样-β聚合物.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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