在社会行为网络中神经表示的转换
Bin Yang1,2, Tomomi Karigo1,2,3, David J Anderson4,5
1Division of Biology and Biological Engineering 140-80, TianQiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA, USA.
Nature
|August 3, 2022
概括
这项研究揭示了终端 (BNSTpr) 神经元的床核在下丘脑中形成性别特异的神经表征,控制男性社会行为过渡,而不是性别识别.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 社会行为 社交行为
背景情况:
- 交配和侵略是天生的社会行为,由皮质下电路调节,包括扩展的杏仁体和下丘脑.
- 终端的床核 (BNSTpr) 整合了性别特异的嗅觉线索和项目到控制交配 (MPOA) 和侵略 (VMHvl) 的下丘脑核.
- 以前的研究表明,男性BNSTpr神经元对于安装和攻击至关重要,有可能识别同类型的性别.
研究的目的:
- 描述 BNSTpr 中的神经表征及其在社会行为期间在下丘脑中的功能转换.
- 研究BNSTpr神经元在性别识别中的作用以及男性社会行为的食欲和消费阶段之间的过渡.
主要方法:
- 在社交行为期间对男性BNSTprEsr1神经元进行成像.
- 化学基因沉默BNSTprEsr1神经元,同时对行为动物的MPOAEsr1或VMHvlEsr1神经元进行成像.
主要成果:
- 在BNSTpr中确定了女性与男性调节神经元的不同种群,女性调节神经元的数量更大.
- 观察到VMHvl中性别调节偏差的反转,在BNSTpr沉默时从男性主导到女性主导.
- 发现BNSTpr静音减弱了MPOA在交配期间从嗅入到安装选择性神经元的切换.
- 证明BNSTprEsr1神经元对于同类物种的性别识别不是必不可少的.
结论:
- BNSTprEsr1神经元在调节下丘脑内特定于性别和行为的神经表征方面发挥着至关重要的作用.
- 这些神经元对于控制男性社会行为从食欲到消费阶段的过渡至关重要.
- 这些发现挑战了BNSTpr神经元主要参与同类物种的性别识别的概念.
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