基于重复的全中心体影响基因组结构和型进化
Paulo G Hofstatter1, Gokilavani Thangavel1, Thomas Lux2
1Department of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, NRW 50829, Germany.
Cell
|August 4, 2022
概括
中介体类型影响基因组结构和进化. 在整个染色体中发现的全中染色体,重塑了3D基因组架构,并通过染色体融合驱动型进化.
科学领域:
- 基因组学
- 进化生物学
- 细胞遗传学
背景情况:
- 大多数真核生物具有单中心染色体和单中心体.
- 在一些植物和动物系中,全中性染色体具有整个长度的中体.
- 了解中粒体类型对基因组组织和进化的影响至关重要.
研究的目的:
- 为了比较基因组组织和与中心体类型相关的进化.
- 调查基于重复的全中心体在 (Rhynchospora spp.) 中的作用 和它们的单中心亲属 (Juncus effusus).
- 阐明向全心转变如何影响3D基因组结构和型进化.
主要方法:
- 三种甲和一个单中心亲属的染色体尺度基因组组.
- 基因组组织的分析,包括3D基因组架构和中间体分布.
- 比较基因组学研究型进化和染色体数量减少/融合事件.
主要成果:
- 通过改变基因组区块, 重新定义了三维基因组结构.
- 在全中心物种中,基因组中分布着成千上万个基于重复的单元.
- 青春期脊髓菌表现出复杂的基因组组织,揭示了八倍体性;R. tenuis表现出减少的染色体数量 (两个染色体).
- 基于重复的全中心体促进的染色体融合是型进化和二倍化的主要驱动因素.
结论:
- 中介体类型对基因组架构和进化轨迹有深远的影响.
- 基于重复的全中心体促进染色体融合,有助于型的多样化和稳定性.
- 这项研究提供了由多种中心分子组织塑造的基因组进化.
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