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荷兰COVID-19后体质症状的持续性:观察性队列研究
Aranka V Ballering1, Sander K R van Zon2, Tim C Olde Hartman3
1Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
很大比例的COVID-19幸存者会出现疲劳和呼吸困难等持续症状. 这项研究通过将其与感染前和对照组进行比较,澄清了哪些症状真正归因于COVID-19后的情况.
科学领域:
- 流行病学
- 传染性疾病
- 公共卫生
背景情况:
- 后COVID-19情况涉及急性感染后持续的症状.
- 之前的研究往往无法解释预先存在的症状或对照人群.
研究的目的:
- 分析长期COVID-19症状的性质,患病率和严重程度.
- 为纠正SARS-CoV-2感染前存在的症状,并控制未感染个体的症状动态.
主要方法:
- 使用来自前性,基于人口的生命线队列研究的数据.
- 在24次重复测量中评估了COVID-19患者和没有患者的23个体质症状.
- 根据年龄,性别和时间,将COVID-19阳性参与者与COVID-19阴性对照进行匹配.
主要成果:
- 确定的持续症状包括胸部疼痛,呼吸困难,疲劳和感官变化 (老年症/无呼吸症).
- 在12.7%的患者中,症状归因于COVID-19,严重程度明显增加.
- 在诊断后90-150天内,核心症状在21.4%的COVID-19阳性人群和8.7%的阴性人群中严重增加.
结论:
- 这项研究提供了对COVID-19后疾病患病率和性质的修正观点.
- 需要进一步研究以了解导致这些持续症状的机制.
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