相关实验视频

Updated: Sep 1, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

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表观遗传阅读器SP140 功能丧失驱动克罗恩病由于不受控制的巨类拓酶

Hajera Amatullah1, Isabella Fraschilla2, Sreehaas Digumarthi3

  • 1Center for the Study of Inflammatory Bowel Disease, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital Research Institute, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA.

Cell
|August 11, 2022
PubMed
概括

斑点蛋白140 (SP140) 的损失通过释放拓酶活性来破坏免疫细胞的功能,从而导致免疫疾病. 抑制拓酶 (TOPs) 挽救了这些缺陷,为SP140相关疾病提供了潜在的治疗方法.

关键词:
克罗恩病博士学位标签: 美国斑点蛋白质多马因染色体表观遗传阅读器炎症性肠道疾病巨细胞一种类型

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