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Updated: Aug 31, 2025

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在多克索鲁比辛心肌病中,TRAF2的蛋白体降解介导了线粒体功能障碍

Rimpy Dhingra1, Inna Rabinovich-Nikitin1, Sonny Rothman1

  • 1Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology (R.D., I.R.-N., S.R., M.G., H.G., V.M., D.S.J., K.N.A., S.D., L.A.K.), Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Circulation
|August 19, 2022
PubMed
概括

doxorubicin (DOX) 治疗降低了TRAF2,这是一种对心脏生存信号至关重要的蛋白质. 这种干扰导致DOX诱导的心脏毒性,使心脏细胞对TNFα介导的死亡敏感.

关键词:
与TNF受体相关的2因子多克索鲁比辛抑制细胞亡蛋白的方法线粒体肌细胞,心脏蛋白酶内酶复合体瘤死亡因子-阿尔法

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