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Updated: Aug 31, 2025

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由pMHC结合的完全组装的瘤特异性T细胞受体的结构

Lukas Sušac1, Mai T Vuong2, Christoph Thomas1

  • 1Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Cell
|August 19, 2022
PubMed
概括

结合癌症特异性-MHC的T细胞受体 (TCR) 结构揭示了T细胞如何识别抗原. 这种结构洞察力表明TCR可以在没有重大前结合变化的情况下被激活,从而影响免疫反应的理解.

关键词:
适应性免疫抗原呈现方式电子显微镜膜蛋白质感应器触发结构细胞生物学超分子复合物

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