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Updated: Aug 29, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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新型抗原呈现细胞对肠道微生物群产生Treg依赖的耐受性

Blossom Akagbosu1, Zakieh Tayyebi2,3, Gayathri Shibu1,4

  • 1Immuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, USA.

Nature
|September 7, 2022
PubMed
概括

研究人员发现了Thetis细胞,一种新型的RORγt+抗原呈现细胞,对于在生命早期建立周围免疫耐受性至关重要. 这些细胞,特别是TC IV亚群,对于产生调节性T细胞至关重要,防止肠道炎症.

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