大脑干ADCYAP1+神经元控制疾病行为的多个方面
Anoj Ilanges1, Rani Shiao1, Jordan Shaked1
1Laboratory of Molecular Genetics, The Rockefeller University, New York, NY, USA.
Nature
|September 7, 2022
概括
研究人员发现特定的脑干神经元控制由细菌内毒素引起的疾病行为. 激活这些神经元会复制疾病反应, 而抑制它们会减弱这些影响,
科学领域:
- 神经科学
- 免疫学
- 行为科学
背景情况:
- 感染会引发适应性疾病行为,
- 这些疾病反应背后的神经机制在很大程度上是未知的.
研究的目的:
- 确定控制疾病行为的特定神经群体.
- 解释大脑在对感染的不同反应中的作用.
主要方法:
- 在LPS治疗后使用FOS表达的全脑活动映射.
- 基因操纵 (TRAP2小鼠) 来重新激活特定的神经元.
- 单核RNA测序用于识别神经群体.
- 抑制神经活动以评估行为影响.
主要成果:
- LPS治疗激活了单独通道 (NTS) 和区域后膜 (AP) 中的特定神经元.
- 这些NTS-AP神经元的重新激活模仿了疾病行为和发烧.
- 这些神经元的抑制减少了LPS诱导的所有疾病行为.
- 在NTS-AP完全重复的LPS效应中,ADCYAP1+神经元的激活.
结论:
- 对于疾病反应,一个特定的NTS-AP神经群体是必要的和足够的.
- 这项研究确立了大脑功能与宿主对感染的反应之间的关键联系.
相关概念视频
Brainstem: Control Centers of Medulla
2.0K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
2.0K
Autonomic Nervous System
9.4K
The autonomic nervous system (ANS) is a critical component of the peripheral nervous system, primarily responsible for regulating involuntary bodily functions and maintaining homeostasis. It functions in tandem with the central nervous system (CNS) to seamlessly coordinate various physiological processes without the need for conscious control.
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
The ANS comprises two main divisions: the sympathetic and parasympathetic divisions. These divisions function antagonistically to maintain a dynamic...
9.4K
Pathophysiology of Vomiting
1.0K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
1.0K
Physiology of Emotion
1.2K
The physiology of emotions is a multifaceted process involving the autonomic nervous system, brain structures, hormones, and neurotransmitters. This intricate interplay dictates how emotions manifest in the body and influence behavior.
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
Autonomic Nervous System
The autonomic nervous system (ANS) plays a critical role in emotional responses by regulating involuntary physiological functions. It consists of two main components: the sympathetic and parasympathetic systems. The sympathetic system...
1.2K
Brainstem
2.8K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
2.8K
The Sympathetic Nervous System
96.4K
Overview
96.4K


