在MOMENTUM 3随机试验中,完全磁悬浮与轴流左心室辅助器件患者的五年结果
Mandeep R Mehra1, Daniel J Goldstein2, Joseph C Cleveland3
1Brigham and Women's Hospital, Boston, Massachusetts.
JAMA
|September 8, 2022
概括
与轴流LVAD相比,完全磁悬浮的离心流左心室辅助装置 (LVAD) 在5年内显著改善存活率并减少不良事件. 这为晚期心力衰竭患者提供了更好的结果.
科学领域:
- 心脏病学
- 医疗器械
- 心脏衰竭的治疗方法
背景情况:
- 持续使用左心室辅助器 (LVAD) 对晚期心力衰竭至关重要.
- 对于LVADs的长期结果没有充分记录.
研究的目的:
- 评估5年复合终点的生存,移植,康复或没有中风或重新手术的LVAD支持.
- 将离心流量 (HeartMate 3) 和轴流量 (HeartMate II) LVAD 的结果进行比较.
主要方法:
- 在MOMENTUM 3试验的5年后续观察.
- 包括2年后接受LVAD治疗的患者.
- 分析了477名患者的数据.
主要成果:
- 离心流动的LVAD (54. 0%) 与轴流动的LVAD (29. 7%) 的5年综合结果明显好.
- 在5年内,离心流动LVAD的总生存率高于轴流动LVAD的58. 4% (43. 7%).
- 离心流发生的中风,出血和血栓等严重不良事件较少.
结论:
- 完全磁悬浮的离心流动LVAD与优异的5年结果有关.
- 这些发现支持离心流动LVAD在晚期心力衰竭的临床使用.
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