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Updated: Aug 28, 2025

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
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由mTOR调节的线粒体新陈代谢限制了菌根诱导的细胞毒性

Antonio J Pagán1, Lauren J Lee2, Joy Edwards-Hicks3

  • 1Molecular Immunity Unit, Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK; MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK; Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

Cell
|September 14, 2022
PubMed
概括

结核耐药性涉及巨细胞的代谢. 通过促进能量代谢,防止ESAT-6等真菌毒素对巨细胞造成损害,从而保护mTOR激酶通路.

关键词:
ESAT-6 甲基毒性类细菌结核菌颗粒瘤死亡在 mTOR巨细胞死亡线粒体新陈代谢氧化化结核病斑马鱼结核病模型

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