胎儿肝脏血造干细胞和祖细胞的独立来源
在PubMed上查看摘要
概括
此摘要是机器生成的。在胎儿发育过程中,造血干细胞 (HSC) 和祖细胞同时从前体中产生,独立于成熟的HSC. 这种途径支持出生前组织和干细胞的快速生长.
科学领域
- 发育生物学
- 血液形成
- 干细胞生物学
背景情况
- 维持造血干细胞 (HSC) 稳态需要平衡自我更新和分化.
- 胎儿发育需要HSC扩张和分化细胞的生长.
- 在胚胎期协调这些过程的机制尚未完全理解.
研究的目的
- 在胎儿发育过程中研究HSC和原始细胞的起源和动力学.
- 阐明肝白血病因子 (HLF) 和EVI1在早期血液形成中的作用.
- 确定胎儿HSCs在出生前对血液细胞的贡献.
主要方法
- 在小鼠体内进行基因追踪.
- 血液形成集群的运动研究.
- 对HLF和EVI1表达的分析.
- 在体内对EVI1进行基因操纵.
- 胎儿HSCs的命运跟踪
主要成果
- 从HLF+前体同时形成HSC和前体,不依赖HSC.
- EVI1表达水平与HSC产生潜力相关.
- 对EVI1的基因操纵改变了HSC和原生输出.
- 胎儿的HSC在出生前对原生细胞和血细胞产生贡献很小.
结论
- 胎儿造血包括干细胞独立的干细胞池和组织快速同时生长的途径.
- EVI1 是从前体产生的 HSC 的关键调节者.
- 胎儿的HSC主要具有长期的功能,对血液生产的直接贡献有限.
相关概念视频
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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Commitment is the process whereby stem cells:
lose their ability to form all cell types and
irreversibly change into a specific type.
The multipotent hematopoietic stem cells, (HSCs), differentiate into the multipotent hematopoietic progenitor cells, (HPCs). The HPCs express many lineage-specific cytokine receptors. Each of these receptors binds specific cytokines, activates distinct signaling pathways, and expresses a particular gene set. The HPCs further differentiate to...
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

