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Updated: Aug 28, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
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从 [3.1.1] 螺旋中合成甲基替代的基生物异构体

Nils Frank1, Jeremy Nugent1, Bethany R Shire1

  • 1Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.

Nature
|September 15, 2022
PubMed
概括

研究人员为药物设计开发了双环[3.1.1] (BCHeps) 作为新型的元生物异构体. 与传统的环相比,这些富含sp3的基因具有更好的代谢稳定性和可溶性.

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