多血管冠状动脉疾病的Everolimus-Eluting支架或绕道手术:多中心随机对照BEST试验的延长后续结果
在PubMed上查看摘要
概括
此摘要是机器生成的。多血管冠状动脉疾病的长期结果显示,皮肤冠状动脉干预 (PCI) 和冠状动脉旁路移植 (CABG) 之间的重大心脏不良事件没有显著差异. 然而,PCI患者的心肌梗塞和重复血管化的发病率较高.
科学领域
- 心脏病学
- 干预心脏病学
- 心脏外科
背景情况
- 在患有多血管冠状动脉疾病的患者中,通过皮肤进行冠状动脉干预 (PCI) 治疗与冠状动脉绕道移植 (CABG) 的长期比较结果数据有限.
- 多血管冠状动脉疾病需要仔细考虑再血管化策略.
研究的目的
- 在患有多血管冠状动脉疾病的患者中,比较PCI与Everolimus排泄支架的长期结果.
- 评估两种重血管化方法之间的主要心脏不良事件,安全终点和死亡率.
主要方法
- 这是一项前性多中心随机对照试验,涉及880名血管多血管冠状动脉疾病患者.
- 患者被分配到使用常利蒙分泌支架或CABG的PCI.
- 随访时间中位数为11. 8年.
主要成果
- 在PCI和CABG之间,主要终点 (死亡,心肌梗塞或目标血管再血管) 没有显著差异 (34. 5%与30. 3%,P=0. 26).
- 在死亡,心肌梗塞或中风的安全性组合中没有显著差异,也没有任何原因的死亡率.
- 与CABG相比,PCI后发生的自发性心肌梗塞 (7. 1% 与 3. 8% 相比,P=0. 031) 和重复血管化 (22. 6% 与 12. 7% 相比,P< 0. 001) 的比率更高.
结论
- 在多血管冠状动脉疾病患者中,PCI和CABG显示长期出现的重大心脏不良事件和全因死亡率相似.
- 与CABG相比,PCI与自发心肌梗塞和重复血管化的风险增加.
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