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Updated: Aug 28, 2025

A Label-free Technique for the Spatio-temporal Imaging of Single Cell Secretions
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生物直角光反应表面用于单细胞间通信分析

Takahiro Kosaka1, Satoshi Yamaguchi1,2, Shin Izuta1

  • 1Department of Chemistry & Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Journal of the American Chemical Society
|September 20, 2022
PubMed
概括

研究人员开发了一种新型的光响应表面,用于创建不同细胞类型的单细胞对. 这一突破使得细胞间通信的详细研究成为可能, 推动了细胞生物学和医学研究.

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Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
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