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Updated: Aug 28, 2025

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
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Published on: May 10, 2022

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针对受体降解的E3无酸酶的抗体向

Hadir Marei1, Wen-Ting K Tsai2, Yee-Seir Kee2

  • 1Discovery Oncology, Genentech, South San Francisco, CA, USA.

Nature
|September 21, 2022
PubMed
概括

研究人员开发了针对蛋白质分解的抗体 (PROTAB) 来降解细胞表面蛋白质. 这种新方法提供了针对蛋白质降解的强大和选择性方法,克服了传统抑制疗法的局限性.

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