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Updated: Aug 28, 2025

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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长的生殖中心具有持久的亲和成熟和克隆迁移

Jeong Hyun Lee1,2,3, Henry J Sutton1,2, Christopher A Cottrell2,3,4

  • 1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, USA.

Nature
|September 21, 2022
PubMed
概括

在初始免疫接种后,长期的生殖中心B细胞 (BGC) 持续超过六个月,显示持续的抗体进化,并在增强后产生高位的中和抗体. 这种长期免疫策略有利于具有挑战性的疫苗目标.

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