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经组织学证明的发性心肌炎的特征和结果
Koshiro Kanaoka1,2, Kenji Onoue1, Satoshi Terasaki1
1Department of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan (K.K., K.O., S.T., T.N., R.K., Y. Saito).
Circulation
|September 27, 2022
概括
充血性心肌炎 (FMP) 是一种严重的心脏病. 年龄较大,心律异常和心脏功能减弱预示着FMP患者在90天内出现更糟糕的结果.
科学领域:
- 心脏病学
- 病理学
- 临床医学
背景情况:
- 充满性心肌炎 (FMP) 是一种罕见的,严重的心肌炎.
- 关于FMP的自然史和预后因素的证据有限.
- 了解FMP对于改善患者的结果至关重要.
研究的目的:
- 确定FMP中不良结果的临床和病理预测因素.
- 分析FMP患者的90天生存率.
- 提供有关FMP预后的见解.
主要方法:
- 在344名经组织学证明的FMP患者中进行了多中心回顾性队列研究.
- 从日本235家心血管培训医院收集的数据 (2012年4月至2017年3月).
- 用于确定预后因素的卡普兰-梅尔,日志等级和考克斯回归分析.
主要成果:
- 在90天后,死亡或心脏移植的累积风险为29%.
- 更糟糕的90天生存预测因素包括年龄较大,非鼻心律,左心室下壁运动 (< 40%) 和心室高心率/肌.
- 严重的组织学损伤 (≥50%的心肌细胞损伤) 预测淋巴细胞性心肌炎的预后会更差.
结论:
- FMP患者面临死亡或心脏移植的高风险.
- 临床发现如年龄,节律和心室功能是关键预后指标.
- 病理发现,特别是淋巴细胞心肌炎,有助于预后.
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