工程聚乙烯糖醇纳米颗粒用于加速血液清理抑制和向药物输送
Yuan Tian1, Zhiliang Gao1, Ning Wang1
1Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
Journal of the American Chemical Society
|September 27, 2022
概括
用聚乙烯糖醇 (PEGylation) 涂覆的工程纳米颗粒避免了加速的血液清除. 这些隐形纳米颗粒可以有效地向癌细胞,
科学领域:
- 生物材料科学
- 纳米技术
- 药物输送系统
背景情况:
- 聚乙烯糖醇 (PEGylation) 增强了纳米粒子 (NP) 的稳定性,但可以导致加速血液清除 (ABC),减少循环时间.
- 这种ABC现象与对抗PEGylated物质的免疫反应有关,包括抗体分泌.
研究的目的:
- 设计隐形的聚乙烯糖醇纳米颗粒 (PEGNP) 绕过ABC现象.
- 用氨酸 (HA) 功能化这些PEGNP用于向癌症治疗和药物输送.
主要方法:
- 制造二硫化物交叉连接的PEGNP,使用化物化物框架-8NP作为模板.
- 在温和条件下同时去除模板和形成PEG NP (pH5.5).
- 用氨酸 (HA) 针对CD44的PEGNP的功能化.
主要成果:
- 工程 PEG NPs 避免了抗 PEG 抗体的分泌,并没有显著加速血液清除,这表明抑制了 ABC 效应.
- 与PEG化脂质体相比,PEGNP对巨细胞吸收的隐藏性更强.
- 具有HA功能的PEG NPs针对CD44表达的癌细胞并有效地抑制瘤生长.
结论:
- 通过抑制ABC现象,工程PEGNP可以克服传统PEGylation的局限性.
- 在保持隐形性质的同时, 氨酸功能化赋予癌细胞向能力.
- 这些新型纳米粒子为改善和向药物输送提供了一个有前途的平台,特别是在癌症治疗方面.
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