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Updated: Aug 27, 2025

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通过对DCAF1进行刻板选择和特定部位的电友性PROTAC进行向蛋白质降解

Yongfeng Tao1, David Remillard1, Ekaterina V Vinogradova1

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92307, United States.

Journal of the American Chemical Society
|September 28, 2022
PubMed
概括

研究人员发现了针对DCAF1进行蛋白质降解的新型亚齐丁烯胺. 这种针对蛋白质降解的突破为化学探测和使用电友PROTAC的药物发现开辟了新的途径.

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