通过可编程折叠自组合乳液滴
Angus McMullen1, Maitane Muñoz Basagoiti2, Zorana Zeravcic3
1Center for Soft Matter Research, New York University, New York, NY, USA.
Nature
|September 28, 2022
概括
研究人员开发了状折叠体,即可编程的DNA互动滴链, 这种方法可以通过控制相互作用序列来创建复杂的材料,从分子到大规模设计都适用.
科学领域:
- 材料科学
- 生物物理
- 纳米技术
背景情况:
- 粒子自组通常需要任意结构的不同构件.
- 具有有限组件类型的系统通常仅限于异国情调的晶体形成.
- 可编程的交互是控制自组装过程的关键.
研究的目的:
- 采用合液滴进行可控粒子自组合的最小模型系统.
- 通过可编程的DNA相互作用来展示特定的几何结构.
- 探索这些结构作为更大材料的构建块的潜力.
主要方法:
- 使用可编程DNA相互作用的合液滴链.
- 在真实空间和时间中观察到滴水组合.
- 将实验观测与计算模拟和理论分析结合起来.
主要成果:
- 通过控制DNA相互作用的序列来开发"体折叠体".
- 通过交替序列成功折叠滴链成11个独特的2D和1个3D结构.
- 证明优化序列和添加组件类型可以编码超过一半的可能的二维几何.
- 观察到有13个+滴滴的孔隙结构的形成.
- 模拟显示,折叠体可以组装成复杂的超体结构 (二元体,带,马赛克).
结论:
- 控制交互序列是指导自组装进入所需几何形状的强大方法.
- 体折叠材料提供了一个多功能平台,用于设计具有可调节性质的材料.
- 这些原则适用于从分子到宏观材料的各种长度尺度.
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