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代谢物d-2HG改变T细胞代谢以损害CD8+T细胞功能

Giulia Notarangelo1, Jessica B Spinelli1, Elizabeth M Perez2,3,4

  • 1Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.

Science (New York, N.Y.)
|September 29, 2022
PubMed
概括

通过向乳酸脱酶 (LDH),瘤产生的d- 2酸 (d- 2HG) 损害了CD8+ T细胞的抗瘤功能. 这种新陈代谢重编程降低了T细胞毒性和干扰素马信号,影响了IDH突变质瘤.

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