降解粘液的 Bacteroides 与加重的移植对宿主疾病联系在一起
Eiko Hayase1, Tomo Hayase1, Mohamed A Jamal1
1Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Cell
|September 30, 2022
概括
通过扩大 Bacteroides thetaiotaomicron,使保护性粘液层降解,美罗抗生素治疗会使肠道移植与宿主疾病 (GVHD) 恶化. 克西洛斯补充剂可以防止这种粘液稀释,从而降低GVHD的风险.
科学领域:
- 微生物组研究
- 免疫学
- 胃肠病学
背景情况:
- 同源造血干细胞移植 (allo-HSCT) 经常因移植对宿主疾病 (GVHD) 而复杂化.
- 肠道微生物群在调节GVHD中起着至关重要的作用,众所周知,广泛的抗生素如卡巴胺会增加其风险.
- 通过抗生素加剧肠道GVHD的确切机制尚不完全理解.
研究的目的:
- 研究一种卡巴胺抗生素 - - 梅罗因如何加剧结肠GVHD的机制.
- 探索肠道微生物群,特别是 Bacteroides thetaiotaomicron (BT) 在美洛诱导的GVHD中的作用.
- 评估营养补充剂的潜力,如糖,以减轻与抗生素相关的GVHD.
主要方法:
- 用于研究结肠GVHD的allo-HSCT小鼠模型.
- 用美罗治疗和微生物组合的评估,重点是 Bacteroides thetaiotaomicron (BT).
- 分析粘素甘氨酸的降解,结肠粘液层厚度和光水平.
- 评估口服西洛斯补充剂的治疗效果
主要成果:
- 在异种小鼠中,梅洛治疗导致了Bacteroides thetaiotaomicron (BT) 的扩张,与恶化的结肠GVHD相关.
- 导致结肠粘液层稀疏和光糖减少.
- 在接受梅罗治疗的小鼠中,口服西洛斯补充剂有效地防止了结肠粘液层的稀薄.
结论:
- 梅洛通过促进 Bacteroides thetaiotaomicron 的生长,从而破坏结肠粘液屏障,从而加剧肠道GVHD.
- 粘蛋白糖因BT的降解是抗生素引起的肠损伤的关键机制.
- 营养策略,包括补充糖,有望抵消抗生素介导的微生物损害,并降低alo-HSCT患者的GVHD风险.
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