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Updated: Aug 26, 2025

Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying DesB Dioxygenase Activity and Inhibition
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在达罗巴克生物合成中以太交联的SAM氧化酶的特征

Hai Nguyen1, I Dewa Made Kresna2, Nils Böhringer2,3

  • 1Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States.

Journal of the American Chemical Society
|October 4, 2022
PubMed
概括

在使用氧气的抗生素达洛巴丁A生物合成中,DarE酶形成了和C-C交叉链. 这种激进的S-adenosylmethionine酶挑战了这种酶类的厌氧功能范式.

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