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Updated: Aug 26, 2025

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
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由STING诱导的调节性B细胞损害了癌症免疫中的NK功能

Sirui Li1,2,3, Bhalchandra Mirlekar1,2, Brandon M Johnson1,3

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Nature
|October 5, 2022
PubMed
概括

干扰素基因刺激剂 (STING) 激活剂可以扩大调控性B细胞,阻碍抗瘤免疫力. 在B细胞中准这种STING- IL-35通路可以通过增强自然杀伤细胞反应来改善癌症治疗.

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