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两个FTD-ALS基因汇聚在内体路径上,诱导TDP-43病理和退化

Wei Shao1, Tiffany W Todd1, Yanwei Wu1

  • 1Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.

Science (New York, N.Y.)
|October 6, 2022
PubMed
概括

前性痴呆和ALS涉及C9orf72和TBK1基因. C9orf72的聚合会损害TBK1,从而恶化神经退行和TDP-43病理.

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