耐药性的行为和多巴胺特征
Lindsay Willmore1, Courtney Cameron1, John Yang1
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Nature
|October 19, 2022
概括
慢性压力对个体的影响不同,多巴胺 (DA) 神经元活动会影响性. 这项研究揭示了在压力期间DA神经元活动如何塑造小鼠的弹性行为.
科学领域:
- 神经科学
- 行为科学
- 压力研究
背景情况:
- 慢性压力对个体的影响有所不同,有些人表现出性,有些人表现出易感性.
- 经过压力后,在性和易受性个体之间观察到中性多巴胺 (DA) 神经元特性上的差异.
- 与压力相关的行为和弹性之间的因果关系尚不清楚.
研究的目的:
- 调查多巴胺神经元活动,压力时的行为和个人弹性差异之间的因果关系.
- 在社会压力期间探索多巴胺信号在核 (NAc) 和尾纹体 (TS) 的作用.
- 为了确定操纵DA神经元活动是否能促进性.
主要方法:
- 在社会失败期间同时记录鼠标行为和DA神经元活动的NAc和TS预测.
- 通过先进的行为量化来识别灵活和易受影响的小鼠的不同策略.
- 在社会失败期间随机和行为定时的NAc投射DA神经元的光遗传刺激.
主要成果:
- 耐受性和易受性小鼠在压力时表现出不同的行为策略和不同的DA神经元活动模式.
- 弹性小鼠在攻击者附近和反击时表现出更高的DA神经元活动.
- 易受攻击的小鼠在攻击和逃跑过程中表现出更高的DA神经元活动.
- 对DA神经元的光遗传激活促进了弹性,并将行为转向与弹性相关的模式.
结论:
- 在NAc中多巴胺神经元的活动与压力时的弹性有因果关系.
- 在社会失败过程中,DA神经元活动的特定模式与不同的行为策略相关.
- 针对DA神经元活动提供了一种促进应激性的潜在途径.
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