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Updated: Aug 24, 2025

Reconstitution of Msp1 Extraction Activity with Fully Purified Components
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Published on: August 10, 2021

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多通道膜蛋白的内膜护理器的机制

Luka Smalinskaitė1, Min Kyung Kim1, Aaron J O Lewis1

  • 1MRC Laboratory of Molecular Biology, Cell Biology Division, Cambridge, UK.

Nature
|October 19, 2022
PubMed
概括

多通道膜蛋白在Sec61后面插入并折叠,而不是通过其侧门. 涉及Asterix和CCD47的PAT复合体形成了一种用于蛋白质生物生成的新型多通路转位子.

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Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry10:24

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In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
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