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Updated: Aug 24, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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E3结合酶适配器的目标是C端的循环胺降解

Saki Ichikawa1, Hope A Flaxman1, Wenqing Xu1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature
|October 19, 2022
PubMed
概括

C终端循环 imides 是由大脑 (CRBN) 识别的新发现的生理降解物. 这一发现揭示了蛋白质降解的自然机制,

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