胰岛素纤维促进了微生物来源的胆汁酸和2型炎症
Mohammad Arifuzzaman1,2,3, Tae Hyung Won4, Ting-Ting Li1,2,3
1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Division of Gastroenterology and Hepatology, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA.
饮食中的胰岛素纤维会改变肠道细菌,增加胆汁酸并引发2型炎症. 这突显了一种新的机制,它将饮食,微生物群和屏障表面的免疫反应联系起来.
科学领域:
- 免疫学
- 微生物学
- 代谢学
背景情况:
- 食物纤维通过短链脂肪酸提供抗炎作用.
- 大多数纤维饮食及其代谢物的免疫调节作用尚不清楚.
研究的目的:
- 研究胰岛素纤维如何影响肠道微生物群和宿主免疫反应.
- 鉴定因胰岛素介导炎症中的特定代谢物.
主要方法:
- 在小鼠中进行微生物测序和非向代谢.
- 对2型炎症标志物的分析 (IL-33,先天性淋巴细胞,乙酸性淋巴细胞).
- 涉及胆汁酸的实验,受体删除和微生物群的殖民化.
主要成果:
- 胰岛素改变了小鼠的微生物组成,增加了胆汁酸,特别是胆汁酸.
- 这种转变引起了肠道和肺部的2型炎症.
- 胆汁酸模仿了胰岛素的作用, 而阻断胆汁酸受体则减少了这种作用.
- 胰岛素的作用依赖于微生物群,并增强了过敏原/ 虫引起的炎症.
结论:
- 饮食中的胰岛素纤维促进了微生物来源的胆酸的产生.
- 这会在屏障表面引发2型炎症.
- 这些发现对过敏性炎症,组织保护和宿主防御有影响.
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