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Updated: Aug 23, 2025

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发光双金属纳米颗粒在肝脏中快速生物转化

Yue Tan1, Wei Cai2, Caiming Luo2

  • 1Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, and Guangdong-Hong Kong-Marco Joint Laboratory of Optoelectronic and Magnetic Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China.

Journal of the American Chemical Society
|November 3, 2022
PubMed
概括

新的金银纳米粒子通过在肝脏中快速转化而避免肝脏封存. 这一策略增强了纳米粒子循环时间,改善了疾病向,并最大限度地减少了纳米毒性,以更好地提供纳米药物.

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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