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预防因人环素引起的功能障碍和心脏功能障碍的运动:英国退欧研究
Stephen J Foulkes1,2,3, Erin J Howden4,3, Mark J Haykowsky2
1Sports Cardiology (S.J.F., K.J., A.M.M., L.W., B.T.C., A.L., L.B., I.W., A.L.G.), Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Circulation
|November 7, 2022
概括
在接受以环素为基础的化疗的乳腺癌患者中,运动训练 (ExT) 没有预防功能障碍,但改善了心肺健康和心脏储备. 坚持ExT是预防功能衰退的关键.
科学领域:
- 癌症学
- 心脏病学
- 运动生理学
背景情况:
- 在乳腺癌幸存者中,以人环素 (AC) 为基础的化疗会增加功能限制和心脏功能障碍的风险.
- 接受AC治疗的早期乳腺癌患者需要进行干预以减轻这些风险.
研究的目的:
- 确定12个月的运动训练 (ExT) 是否可以减轻接受AC治疗的乳腺癌患者的功能障碍.
- 评估ExT对心肺健康 (VO2峰值) 和预防心脏功能障碍的影响.
主要方法:
- 这是一项为期12个月的随机对照试验,涉及104名预定接受AC的乳腺癌早期患者.
- 参与者被随机分配到ExT (有氧和耐药性) 或常规治疗 (UC).
- 功能测量包括心肺运动测试,心脏核磁共振,心声学和生物化学 (热素,BNP).
主要成果:
- 在4个月后减弱功能障碍,但在12个月后却没有.
- 每项方案分析显示,在12个月后,ExT预防了功能障碍 (UC的0%与20%,P=0. 005).
- ExT提高了VO2峰值3. 5毫升·公斤-1分钟-1,增加了心脏输出量,中风量和喷射分数储备. 化学疗法后的热血素与ExT的增加较小.
结论:
- 12个月的ExT并没有减轻功能障碍,但在接受AC的乳腺癌患者中显著改善了心肺健康和心脏储备.
- 遵守ExT对于预防功能障碍至关重要.
- 在接受化疗的乳腺癌患者中,ExT对心血管有显著的益处.
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