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Updated: Aug 21, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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分子CELMoD化合物是大脑形状的调节剂

Edmond R Watson1, Scott Novick2,3, Mary E Matyskiela4

  • 1Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|November 15, 2022
PubMed
概括

CELMoD剂利用Cereblon (CRBN) 进行向蛋白质降解. 新的冷电磁结构显示CELMoD化合物诱导CRBN

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