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相关概念视频

Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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There have been five major extinction events throughout geological history, resulting in the elimination of biodiversity, followed by a rebound of species that adapted to the new conditions. In the current geological epoch, the Holocene, there is a sixth extinction event in progress. This mass extinction has been attributed to human activities and is thus provisionally called the Anthropocene. In 2019 the human population reached 7.7 billion people and is projected to comprise 10 billion by...
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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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相关实验视频

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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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由于蝙蝠生态的快速变化,

Peggy Eby1,2,3, Alison J Peel2, Andrew Hoegh4

  • 1School of Biological, Earth, and Environmental Sciences, University of New South Wales, Sydney, New South Wales, Australia.

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概括

蝙蝠病原体对公众健康构成风险. 这项研究揭示了土地使用和气候变化如何影响蝙蝠的行为,

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科学领域:

  • 生态学
  • 流行病学
  • 保护生物学

背景情况:

  • 蝙蝠传播的病原体是越来越严重的公共卫生问题,
  • 确定环境变化与蝙蝠病原体溢出相关的机制仍然是一个重大挑战.
  • 之前的研究往往缺乏将宿主生态,行为和病毒动态与溢出事件联系起来所需的详细数据.

研究的目的:

  • 调查土地使用变化,蝙蝠行为和亨德拉病毒蔓延事件之间的机制联系.
  • 分析25年的环境因素,蝙蝠生态和病毒传播数据.
  • 开发蝙蝠病毒传播风险的预测模型.

主要方法:

  • 收集和分析了25年来澳大利亚土地使用变化,蝙蝠行为和亨德拉病毒传播事件的数据.
  • 使用集成贝叶斯网络模型来识别环境变量和溢出集群之间的关系.
  • 研究了营养压力,息地变化和气候对蝙蝠居住和行为的影响.

主要成果:

  • 蝙蝠因环境变化而改变其行为,
  • 土地使用变化和气候相互作用造成了蝙蝠存在的增加和周期性食物短缺的条件,
  • 剩余森林的冬季开花模式与溢出风险的降低有关.

结论:

  • 通过改变宿主行为和生态, 虫病毒的传播风险增加.
  • 这项研究为了解蝙蝠病毒传播和制定生态干预措施提供了框架.
  • 长期的生态数据对于预测和减轻来自野生动物库的流行病威胁至关重要.