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Updated: Aug 21, 2025

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin
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通过胆固醇调节障碍,APOE4 损害了骨髓化

Joel W Blanchard1,2,3, Leyla Anne Akay1,2,4, Jose Davila-Velderrain4,5

  • 1Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

Nature
|November 17, 2022
PubMed
概括

在阿尔茨海默病模型中,阿波利波蛋白E4 (APOE4) 基因变异显著改变脑基因表达和胆固醇运输,导致骨髓缩和记忆障碍. 针对胆固醇运输的干预措施可能会带来治疗效益.

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相关概念视频

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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