交叉性质的交配是普遍存在的,并夸大了遗传相关性估计
Richard Border1,2,3, Georgios Athanasiadis4,5, Alfonso Buil4,6
1Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
概括
交叉特征配对 (xAM) 为人类特征之间的遗传相关性提供了一个新的解释. 这种交配模式,不仅仅是性,显著影响了特征相似性,这表明以前的遗传重叠估计可能被高估了.
科学领域:
- 人类遗传学
- 行为遗传学
- 定量遗传学
背景情况:
- 人类特征之间的遗传相关性通常归因于变性,其中一个基因影响多个特征.
- 然而,观察到的遗传相关性的替代解释需要调查,以避免高估遗传相似性.
研究的目的:
- 引入和评估交叉特征的选择性交配 (xAM) 作为遗传相关性的替代解释.
- 评估xAM可以在多大程度上解释人类特征之间的遗传相关性,包括精神疾病.
主要方法:
- 表型交叉对应的估计.
- 在表型交叉伴侣相关性和遗传相关性估计之间的关联分析.
- 交叉特征偶数/奇数染色体多基因分数相关性以检测历史的xAM.
主要成果:
- 交叉性质分类交配 (xAM) 影响了许多表型,并与遗传相关性估计有很强的联系 (R2=74%).
- 现有的xAM可信地解释了遗传相关性估计的重要部分.
- 一些精神疾病之间的遗传相关性仅与xAM一致,证据表明在遗传层面上有xAM的历史.
结论:
- 交叉特征交配 (xAM) 是人类特征之间的遗传关联的一个重要因素.
- 由于忽视了xAM的影响,此前对表型之间遗传相似性的估计可能被高估.
- 对xAM的进一步研究对于精确解释遗传相关性研究至关重要.
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