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Updated: Aug 20, 2025

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作为因特林促进向蛋白质降解的分子降解剂的双功能化合物

Jiwei Zheng1, Wanyi He1,2, Jing Li1,2

  • 1Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China.

Journal of the American Chemical Society
|November 23, 2022
PubMed
概括

研究人员开发了一种新的整合素辅助溶酶分解 (IFLD) 方法,以消除细胞外和细胞膜蛋白. 这种策略使用双功能降解剂来向蛋白质进行溶酶体分解,为化学生物学和药物发现提供了新的工具.

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