社会创伤涉及横隔膜电路,以封闭社会奖励
Long Li1,2, Romain Durand-de Cuttoli1,2, Antonio V Aubry1,2
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nature
|November 30, 2022
概括
社会创伤可能会损害社会奖励处理,导致避免. 在小鼠中,侧隔膜神经素 (NTLS) 神经元中的压力诱导的过度活动通过改变奖励感知来驱动这种社会回避.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 精神病学是一个精神病学.
背景情况:
- 创伤性社会经历与人类的精神疾病有关.
- 社会创伤可能会损害大脑的奖励功能,导致社会回避.
- 动物的慢性社会失败压力 (CSDS) 模型研究了压力易感性和弹性.
研究的目的:
- 研究CSDS对小鼠社会奖励的影响.
- 为了识别社会创伤后社会回避的基础的神经机制.
主要方法:
- 慢性社会失败压力 (CSDS) 模型在雄性和雌性小鼠中.
- 行为测试用于测量社会互动和奖励.
- 全脑Fos映射,体内Ca2+成像和全细胞记录.
- 特定神经元群体的光遗传和化学遗传操纵.
主要成果:
- 一组小鼠 (易感,SUS) 在CSDS后表现出社会回避和缺乏社会奖励.
- 非社会压力因素没有影响社会奖励.
- 压力/威胁响应侧隔膜神经素 (NTLS) 神经元被社会相互作用激活,特别是在SUS小鼠中.
- 对NTLS神经元的操纵调节了社会互动和奖励.
结论:
- 在易受影响的小鼠中,CSDS诱导了社会回避,这与受损的社会奖励处理有关.
- 在SUS小鼠中,过度活跃的NTLS神经元可能会将社会目标视为威胁,包括社会奖励.
- NTLS神经元代表了压力诱导的社会缺陷的潜在治疗标.
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